Shahriar Dabiri; Hadiseh Zakeridana; Manzoumeh Shamsi Meymandi; Abbass Etminan; Jalal Azmandian; Simindokhet Habibzadeh; Farzaneh Khazanfari; Saeideh Parvaresh
Volume 8, Issue 4 , October 2013, , Pages 255-262
Abstract
Background & Objectives: Chronicity of lupus nephritis (LN) should be considered for interaction of cell mediated immunity (CMI) and dendritic cells in glomeruli and tubulointerstitial areas. In this study establishment of immunohistopathological changes of dendritic cells and other immune effector ...
Read More
Background & Objectives: Chronicity of lupus nephritis (LN) should be considered for interaction of cell mediated immunity (CMI) and dendritic cells in glomeruli and tubulointerstitial areas. In this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed.
Materials & Methods: Renal needle biopsies of 35 cases of lupus nephritis and 35 cases of other causes of persistent proteinuria were compared for immunohistochemistry for plasmacytoid (CD123), myeloid (CD11c) dendritic cells, macrophages (CD68) and lymphocytes (CD4) markers. Statistical analysis of the data was performed using Spearman and Pearson correlation or ANOVA and t- student test (P < 0.05).
Results:Significant difference of glomerular and interstitial spaces for presence of myeloid-plasmacytoid dendritic cells and lymphocytes except macrophages between lupus nephritis and other causes of persistent proteinuria have found (P<0.001). Positive significant correlations were observed between glomerular presentation of myeloid dendritic cells and chronicity index but not with other markers in lupus nephritis (P <0.001). Statistically significant changes between presence of all markers and activity index were not observed (P >0.05).
Conclusions: The myeloid dendritic cells might have synergistic role with other immune cells in pathogenesis and progression or chronicity of lupus nephritis.
Hadiseh Zakeridana; Ali Naderi; Ahmad Ahangaran; Shahriar Dabiri
Volume 8, Issue 3 , July 2013, , Pages 178-183
Abstract
Inflammatory myofibroblastic tumor is an uncommon benign neoplasm and its presentation in small bowel is rare. Due to clinical manifestation, laboratory data and radiologic results, there is an increased risk of over diagnosis as malignant tumors particularly malignant lymphoma in childhood therefore ...
Read More
Inflammatory myofibroblastic tumor is an uncommon benign neoplasm and its presentation in small bowel is rare. Due to clinical manifestation, laboratory data and radiologic results, there is an increased risk of over diagnosis as malignant tumors particularly malignant lymphoma in childhood therefore may be resulting in wrong therapeutic approach. However pathologic findings could be demonstrated definite diagnosis based on markedly proliferation of bland looking spindle cells which their presence can be confirmed by immunohistochemistry staining to show myofibroblastic differentiation. We describe here an unusual presentation of inflammatory myofibroblastic tumor of the terminal ileum in a 19-month-old girl who presented with anemia, eosinophilia, intestinal obstruction, focal ossification and dystrophic calcification within the tumor.
