Mina Majdi; Hana Saffar; Alireza Ghanadan
Volume 11, Issue 5 , October 2016, , Pages 423-426
Abstract
Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The ...
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Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The main cause remains unclear, but trauma is presumed to be a precipitating factor, as most reported cases have a history of antecedent cutaneous injury. Here we present a case of CMSC in a 51 yr old man, presented with a painless deep-seated dermal nodule in the medial aspect of left ankle without history of any trauma or surgery in this site. Immuno-histochemistry study reveals positive reaction for CD68 in the cystic wall and negative reactions for S-100. CMSC is a unique lesion and worthy to attention, and should be included in the differential diagnosis of deep dermal cutaneous cysts.
Kambiz Kamyab-Hesari; Zahra Safaei-Naraghi; Alireza Ghanadan; Azita Nikoo; Mojtaba Sabaghi
Volume 9, Issue 4 , October 2014, , Pages 251-256
Abstract
Background & Objectives: Accurate differentiation of eczema and psoriasis can be difficult, especially in areas of palm and sole. This study was designed to evaluate histopathological features and identify statistically significant parameters in distinguishing palmoplantar psoriasis from eczema ...
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Background & Objectives: Accurate differentiation of eczema and psoriasis can be difficult, especially in areas of palm and sole. This study was designed to evaluate histopathological features and identify statistically significant parameters in distinguishing palmoplantar psoriasis from eczema of these regions in patients referring to Razi Skin Hospital, Tehran, Iran. Methods: In a cross-sectional study, the patients referring to Razi Skin Hospital were subjected. Biopsies of 36 patients with palmoplantar psoriasis and 16 patients with eczema of these regions were collected from archive of pathology. All of the biopsies were examined blind to the clinical diagnosis by four dermatopathologists separately and data collection forms were completed. Then obtained data were analyzed by SPSS software. Results: The females were more affected than males. There was no difference on involving palm and sole between psoriasis and eczema. Hypogranulosis (P<0.0001), Monro’s microabscess (P<0.0001), tortuous blood vessels in papillary dermis (P<0.0001), suprapapillary plate thinning (P=0.020), confluent parakeratosis (P=0.044) and spongiform pustule (P=0.047) were found to be statistically significant contributors to the clinicopathological concordance in cases of psoriasis. Plasma mounds (P=0.022) were significantly associated with diagnosis of eczema. Conclusion: Psoriasis was more common than eczema in the palms. Histopathologic finding like hypogranulosis, Monro’s microabscess, tortuous blood vessels in papillary dermis, suprapapillary plate thinning, confluent parakeratosis and spongiform pustule had significant relationship with psoriasis and might be useful for its diagnosis.
